The mission of the Placebo Beyond Opinions (PBO) Center is to promote innovative interdisciplinary investigation of the placebo phenomenon and to nurture a higher educational program on placebo research, involving a collaboration of internationally recognized leaders in the field. The PBO Center will promote rigorous research on the mechanisms of placebo effects and how these effects influence variability in symptoms, variability of responses to treatment, and variability in the perception of clinical encounters based on socio-economic factors, disparities, and diversity related to understudied populations. The PBO Center will strive to accomplish these goals by advancing research that can be translated into better clinical trials, educating future generations of clinicians to incorporate knowledge of placebo effects in their practice, and serving as a reference point for incorporating placebo research toward precision medicine.